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Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] Open Access

Helical nanofibres play key roles in many biological processes. Entanglements between helices can aid gelation by producing thick, interconnected fibres — for example the strain-stiffening of fibrin, actin and collagen under tension — but the details of this process are poorly understood. Herein we describe the assembly of an achiral oligo(urea) peptidomimetic compound into supramolecular helices. Aggregation of adjacent helices leads to the formation of fibrils, which further intertwine to produce high-fidelity braids with periodic crossing patterns. A braid-theory analysis suggests that braiding is governed by rigid topological constraints, and that branching occurs due to crossing defects in the developing braids. Mixed-chirality helices assemble into relatively complex, odd-stranded braids, but can also form helical bundles by undergoing inversions of chirality. The oligo(urea) assemblies are also highly sensitive to chiral amplification, proposed to occur through a majority rules mechanism — trace chiral materials can promote the formation of gels containing only homochiral helices.

Descriptions

Resource type
Dataset
Contributors
Creator: Steed, Jonathan 1
Contact person: Steed, Jonathan 1
Editor: Steed, Jonathan 1
1 Durham University
Funder
Engineering and Physical Sciences Research Council
Research methods
Other description
Keyword
Gels
Subject
Colloids
Nanofibers
Location
Language
Cited in
Identifier
ark:/32150/r2cz30ps655
doi:10.15128/r2cz30ps655
Rights
Creative Commons Attribution 4.0 International (CC BY)

Publisher
Durham University
Date Created

File Details

Depositor
J.W. Steed
Date Uploaded
Date Modified
29 October 2020, 10:10:43
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Characterization
File format: zip (ZIP Format)
Mime type: application/zip
File size: 4799813267
Last modified: 2019:05:13 11:54:43+01:00
Filename: BraidsResearchData.zip
Original checksum: 3d0c77f14b515258249fd235700e7329
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User N. Syrotiuk has updated Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] over 3 years ago
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User N. Syrotiuk has added a new version of Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] almost 5 years ago
User J.W. Steed has updated Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] about 5 years ago
User J.W. Steed has updated Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] about 5 years ago
User J.W. Steed has updated Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] about 5 years ago
User N. Syrotiuk has updated Braiding, branching and chiral amplification of nanofibres in supramolecular gels [dataset] over 5 years ago
User N. Syrotiuk has updated Research Data for Braiding, branching and chiral amplification of nanofibres in supramolecular gels over 5 years ago
User J.W. Steed has updated Research Data for Braiding, branching and chiral amplification of nanofibres in supramolecular gels over 5 years ago
User J.W. Steed has deposited Braids Research Data.zip over 5 years ago