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Data and Software for Degiacomi et al, Structure, 2017 Open Access

Research paper highlights: - Accounting for protein dynamics is key to measurement of cross-linking distances. - DynamXL is software that explicitly accommodates dynamics in cross-linking - DynamXL models side-chain rotamers and allows analysis of structural ensembles. - This method improves data interpretation and protein docking performance.

Descriptions

Resource type
Dataset
Contributors
Creator: Degiacomi, Matteo T. 1
Contact person: Degiacomi, Matteo T. 1
Data collector: Degiacomi, Matteo T. 1
Data curator: Degiacomi, Matteo T. 1
Creator: Benesch, Justin L. P. 2
Contact person: Benesch, Justin L. P. 2
Creator: Schmidt, Carla 3
Creator: Baldwin, Andrew J. 2
1 Durham University, UK
2 University of Oxford, UK
3 Martin Luther University Halle-Wittenberg, Germany
Funder
Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Biotechnology and Biological Sciences Research Council
Engineering and Physical Sciences Research Council
Royal Society
Research methods
Other description
Data and Software supporting Degiacomi et al study about a new method and associated software, DynamXL, that accommodates intrinsic protein dynamics in the modelling of cross-linking data. This approach substantially reduces error rates, leading to higher confidence in structure assessment and improved protein-protein docking.
Keyword
cross-linking
molecular modelling
protein docking
mass spectrometry
computational structural biology
Subject
Molecular structure
Proteins--Crosslinking
Mass spectrometry
Computational biology
Computer software
Location
Language
English
Cited in
Identifier
ark:/32150/r27s75dc36z
doi:10.15128/r27s75dc36z
Rights
All rights reserved All rights reserved
Publisher
Durham University
Date Created

File Details

Depositor
M.T. Degiacomi
Date Uploaded
Date Modified
13 October 2017, 10:10:03
Audit Status
Audits have not yet been run on this file.
Characterization
File format: x-gzip (GZIP Format, GZIP)
Mime type: application/x-gzip
File size: 846926318
Last modified: 2017:10:12 16:26:24+01:00
Filename: 2017_Structure_dynamxl.tar.gz
Original checksum: b7b88e0566172fe88991dc984abd4323
Activity of users you follow
User Activity Date
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago
User S. Palucha has updated Data and Software for Degiacomi et al, Structure, 2017 about 1 year ago