Supporting data: Exploring the links between peptoid antibacterial activity and toxicity

Cobb, Steven (Department of Chemistry, Durham University, UK); Bolt, H. L. (Department of Chemistry, Durham University, UK); Eggimann, G. A. (Department of Chemistry, Durham University, UK); Jahoda, C. A. B.   (School of Biological and Biomedical Sciences, Durham University, UK); Zuckermann, R. N. (Molecular Foundry, Lawrence Berkeley National Laboratory, USA); Sharples, G. J. (School of Biological and Biomedical Sciences, Durham University, UK)

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Supporting data: Exploring the links between peptoid antibacterial activity and toxicity Open Access

Abstract form article: Peptides are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicity data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.

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Resource type: Other
Contributors: Creator: Bolt, H. L. ¹
Creator: Eggimann, G. A. ¹
Creator: Jahoda, C. A. B. ²
Creator: Zuckermann, R. N. ³
Contact person: Sharples, G. J. ²
Creator: Sharples, G. J. ²
Creator: Cobb, Steven ¹
Contact person: Cobb, Steven ¹

¹ Department of Chemistry, Durham University, UK
² School of Biological and Biomedical Sciences, Durham University, UK
³ Molecular Foundry, Lawrence Berkeley National Laboratory, USA
Funder: Engineering and Physical Sciences Research Council
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Cited in: doi:10.1039/C6MD00648E
Identifier: ark:/32150/r1zg64tk92g
Publisher: Durham University
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