Supporting data: Exploring the links between peptoid antibacterial activity and toxicity

Cobb, Steven (Department of Chemistry, Durham University, UK); Bolt, H. L. (Department of Chemistry, Durham University, UK); Eggimann, G. A. (Department of Chemistry, Durham University, UK); Jahoda, C. A. B.   (School of Biological and Biomedical Sciences, Durham University, UK); Zuckermann, R. N. (Molecular Foundry, Lawrence Berkeley National Laboratory, USA); Sharples, G. J. (School of Biological and Biomedical Sciences, Durham University, UK)

Download the full-sized Document

Actions

Download Analytics Citations

Export to: EndNote | Zotero | Mendeley

Collections

This file is not currently in any collections.

Supporting data: Exploring the links between peptoid antibacterial activity and toxicity Open Access

Abstract form article: Peptides are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicity data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.

Descriptions

Resource type: Other
Contributors: Creator: Bolt, H. L. ¹
Creator: Eggimann, G. A. ¹
Creator: Jahoda, C. A. B. ²
Creator: Zuckermann, R. N. ³
Contact person: Sharples, G. J. ²
Creator: Sharples, G. J. ²
Creator: Cobb, Steven ¹
Contact person: Cobb, Steven ¹

¹ Department of Chemistry, Durham University, UK
² School of Biological and Biomedical Sciences, Durham University, UK
³ Molecular Foundry, Lawrence Berkeley National Laboratory, USA
Funder: Engineering and Physical Sciences Research Council
Research methods
Other description
Keyword
Subject
Location
Language
Cited in: doi:10.1039/C6MD00648E
Identifier: ark:/32150/r1zg64tk92g
Publisher: Durham University
Date Created

File Details

Depositor: S.L. Cobb
Date Uploaded: 26 January 2017, 14:01:52
Date Modified: 20 February 2017, 15:02:07
Audit Status: Audits have not yet been run on this file.
Characterization: File format: msword (Microsoft Word)

Mime type: application/msword

File size: 22016

Last modified: 2017:01:26 14:15:21+00:00

Filename: Exploring the links between peptoid antibacterial activity and toxicity.doc

Original checksum: f02f1f3bbe5d7915621ecd856ef26ab7

File title: null

File author: Steven Cobb

Page count: 1

File language: U.S. English

Word count: 14

Character count: 85

Activity of users you follow
User Activity	Date
User S.L. Cobb has updated Exploring the links between peptoid antibacterial activity and toxicity.doc	about 7 years ago
User S.L. Cobb has deposited Exploring the links between peptoid antibacterial activity and toxicity.doc	about 7 years ago