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Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] Open Access
Individuals with greater exposure to pathogens in early life have chronically lower levels of C-reactive protein (CRP) compared to those developing in less challenging environments. Such differences affect health in later life, especially risks for other inflammatory and metabolic disorders. Here, we compare levels of salivary CRP between 452 first and second-generation migrant British-Bangladeshis, adjusting for gender, waist circumference and pathogen exposures in early life. We hypothesised that first generation migrants who spent their childhoods in Bangladesh, where disease burden is high, would have chronically lower CRP levels than second-generation British-Bangladeshis brought up in the UK. Saliva samples were analysed for CRP levels using ELISAs, and subjects were measured to obtain anthropometric data. Participants also completed a 129-item questionnaire requesting supplemental information about demographic, socioeconomic, lifestyle and health histories. Data were analysed using multiple linear regression and ordered logistic regression. Results supported our hypothesis with first-generation Bangladeshis having chronically lower levels of salivary CRP. Significant covariates included waist circumference and gender but not disease exposures. Higher CRP in second-generation Bangladeshis might exacerbate risks for other inflammatory disorders including type 2 diabetes and cardiovascular diseases to which South Asians are susceptible.
- Resource type
Cooper, Gillian D.
Kasim, Adetayo 1
1 Durham University
Economic and Social Research Council
- Research methods
- Other description
- C-reactive proteins
Early life development
North East, England, United Kingdom
London, England, United Kingdom
- Cited in
- Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC)
- Date Created
- G.R. Bentley
- Date Uploaded
- 12 February 2021, 14:02:46
- Date Modified
- 16 February 2021, 15:02:30
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- Audits have not yet been run on this file.
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