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Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] Open Access

Individuals with greater exposure to pathogens in early life have chronically lower levels of C-reactive protein (CRP) compared to those developing in less challenging environments. Such differences affect health in later life, especially risks for other inflammatory and metabolic disorders. Here, we compare levels of salivary CRP between 452 first and second-generation migrant British-Bangladeshis, adjusting for gender, waist circumference and pathogen exposures in early life. We hypothesised that first generation migrants who spent their childhoods in Bangladesh, where disease burden is high, would have chronically lower CRP levels than second-generation British-Bangladeshis brought up in the UK. Saliva samples were analysed for CRP levels using ELISAs, and subjects were measured to obtain anthropometric data. Participants also completed a 129-item questionnaire requesting supplemental information about demographic, socioeconomic, lifestyle and health histories. Data were analysed using multiple linear regression and ordered logistic regression. Results supported our hypothesis with first-generation Bangladeshis having chronically lower levels of salivary CRP. Significant covariates included waist circumference and gender but not disease exposures. Higher CRP in second-generation Bangladeshis might exacerbate risks for other inflammatory disorders including type 2 diabetes and cardiovascular diseases to which South Asians are susceptible.

Descriptions

Resource type
Dataset
Contributors
Creator: Bentley, Gillian 1
Begum, Khurshida
Cooper, Gillian D.
Nahar, Papreen
Akhter, Nasima
Kasim, Adetayo 1
1 Durham University
Funder
Economic and Social Research Council
Research methods
Other description
Keyword
C-reactive proteins
Inflammation
Immunology
Early life development
Bangladeshis
Migration
Subject
Location
North East, England, United Kingdom
London, England, United Kingdom
Language
Cited in
Identifier
ark:/32150/r1xk81jk394
doi:10.15128/r1xk81jk394
Rights
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC)

Publisher
Durham University
Date Created

File Details

Depositor
G.R. Bentley
Date Uploaded
Date Modified
16 February 2021, 15:02:30
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Characterization
File format: zip (ZIP Format)
Mime type: application/zip
File size: 760145
Last modified: 2021:02:15 11:31:03+00:00
Filename: BentleyCRPDatatoDRO-r1xk81jk394.zip
Original checksum: 5e970ad5396bf41b240bd9085a7817b7
Activity of users you follow
User Activity Date
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 14 days ago
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 14 days ago
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 15 days ago
User N. Syrotiuk has added a new version of Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 15 days ago
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 15 days ago
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 15 days ago
User N. Syrotiuk has updated Developmental effects on C-reactive protein (CRP) levels among migrant Bangladeshis in the UK [dataset] 15 days ago
User G.R. Bentley has updated BentleyCRPDatatoDRO.zip 18 days ago
User G.R. Bentley has deposited BentleyCRPDatatoDRO.zip 18 days ago