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A Tailored Graphene Supramolecular Gel for Pharmaceutical Crystallization [dataset] Open Access

A graphene-based supramolecular gel was designed and prepared to control the crystallization process and polymorphism of pharmaceuticals. The gelators were modified at the end segments with pyrene moieties, which spontaneously interact with the graphene surface by aromatic stacking interaction resulting in graphene-incorporated supramolecular gel linked by noncovalent interactions between urea groups. When graphene was included into the gel, the critical gel concentration and system rigidity changed significantly, indicating that the gelator forms a close interaction with the graphene. The material was confirmed as a true nanocomposite gel system by electron microscopy. Further the graphene was oxidatively modified to obtain hydroxylated graphene (Gr-OH), which was successfully incorporated into the gel system to serve as a medium for pharmaceutical crystallization. Glycine (GLY), caffeine (CAF) and aripiprazole (APZ) were selected as model drugs for gel surface crystallization and gel phase crystallization by Gr-OH hybrid gels. Incorporation of Gr-OH in the gel allowed close interaction by hydrogen bonding with drug molecules, resulting in different polymorphs of GLY, CAF and APZ compared to solution crystallization and shorter induction time of CAF compared to native gel.

Descriptions

Resource type

Dataset

Contributors

Creator: Steed, Jonathan ¹
Contact person: Steed, Jonathan ¹
Editor: Steed, Jonathan ¹
Data collector: Qi Zhang ¹
Editor: Qi Zhang ¹

¹ Durham University, UK

Funder

Chinese Scholarship Council
EPSRC

Research methods

Other description

Keyword

Gels
Polymorphism
Graphene
Crystallization

Subject

Chemistry

Location

Language

English

Cited in

Identifier

ark:/32150/r16969z0815
doi:10.15128/r16969z0815

Rights

Creative Commons Attribution 4.0 International (CC BY)

Publisher

Durham University

Date Created

27/11/2024

File Details

Depositor

J.W. Steed

Date Uploaded

27 November 2024, 14:11:34

Date Modified

27 November 2024, 16:11:40

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Characterization

File format: zip (ZIP Format)

Mime type: application/zip

File size: 2146508

Last modified: 2024:11:27 14:54:42+00:00

Filename: Underlying data for A Tailored Graphene Supramolecular Gel for Pharmaceutical Crystallization.zip

Original checksum: ee003174da3d2e46b075becdc7f9e0f5