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A Tailored Graphene Supramolecular Gel for Pharmaceutical Crystallization [dataset] Open Access

A graphene-based supramolecular gel was designed and prepared to control the crystallization process and polymorphism of pharmaceuticals. The gelators were modified at the end segments with pyrene moieties, which spontaneously interact with the graphene surface by aromatic stacking interaction resulting in graphene-incorporated supramolecular gel linked by noncovalent interactions between urea groups. When graphene was included into the gel, the critical gel concentration and system rigidity changed significantly, indicating that the gelator forms a close interaction with the graphene. The material was confirmed as a true nanocomposite gel system by electron microscopy. Further the graphene was oxidatively modified to obtain hydroxylated graphene (Gr-OH), which was successfully incorporated into the gel system to serve as a medium for pharmaceutical crystallization. Glycine (GLY), caffeine (CAF) and aripiprazole (APZ) were selected as model drugs for gel surface crystallization and gel phase crystallization by Gr-OH hybrid gels. Incorporation of Gr-OH in the gel allowed close interaction by hydrogen bonding with drug molecules, resulting in different polymorphs of GLY, CAF and APZ compared to solution crystallization and shorter induction time of CAF compared to native gel.

Descriptions

Resource type
Dataset
Contributors
Creator: Steed, Jonathan 1
Contact person: Steed, Jonathan 1
Editor: Steed, Jonathan 1
Data collector: Qi Zhang 1
Editor: Qi Zhang 1
1 Durham University, UK
Funder
Chinese Scholarship Council
EPSRC
Research methods
Other description
Keyword
Gels
Polymorphism
Graphene
Crystallization
Subject
Chemistry
Location
Language
English
Cited in
Identifier
ark:/32150/r16969z0815
doi:10.15128/r16969z0815
Rights
Creative Commons Attribution 4.0 International (CC BY)

Publisher
Durham University
Date Created
27/11/2024

File Details

Depositor
J.W. Steed
Date Uploaded
Date Modified
27 November 2024, 16:11:40
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File format: zip (ZIP Format)
Mime type: application/zip
File size: 2146508
Last modified: 2024:11:27 14:54:42+00:00
Filename: Underlying data for A Tailored Graphene Supramolecular Gel for Pharmaceutical Crystallization.zip
Original checksum: ee003174da3d2e46b075becdc7f9e0f5
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