Designing Lenalidomide Cocrystals with an Extended Release Profile for Improved Pulmonary Drug Delivery
Martin A. Screen[1], Gary Tomkinson[2], James F. McCabe[2], Sean Askin[3], Clare S. Mahon[1], Mark R. Wilson[1], Jonathan W. Steed[1,*]

[1]Durham University, Department of Chemistry, South Road, Durham DH1 3LE, United Kingdom
[2]Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, United Kingdom
[3]Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom. 
*Tel: +44 191 334 2085; 
Email: jon.steed@durham.ac.uk


List of DOI contents:

COCRYSTAL CHARACTERISATION
- XRPD of LDM (Form A) obtained by drying Form B (.xlsx)
- DSC analyses of LDM (Form A) in duplicate (.001)
- TGA analyses of LDM (Form A) in duplicate (.tri)
- XRPD of lenalidomide melamine non-stoichiometric hydrate (cocrystal 1) produced by slurry (.xy)
- XRPD of cocrystal 1 produced by manual grinding (.csv)
- XRPD of lenalidomide melamine methanol hemihydrate (cocrystal 2) produced by L.A.G. (.xy)
- IR of cocrystal 2 produced by L.A.G. (.csv)
- XRPD of cocrystal 2 after slurry in water (.xy)
- 1H NMR spectrum of cocrystal 2 before and after slurry in water (.jdx)
- DSC analysis of cocrystal 1 (.001)
- TGA analysis of cocrystal 1 (.tri) 
- DSC analysis of cocrystal 2 (.001)
- TGA analysis of cocrystal 2 (.tri)
- VT-XRPD patterns of cocrystal 1 at 30, 140, 150, 160, 170, 180, 230, 260 and 30 (cool) degrees centigrade (.xy)
- VT-XRPD patterns of cocrystal 2 at 30, 140, 150, 170, 260 degrees centigrade (.xy)
- Heat-cool-heat DSC analysis of cocrystal 1 (.001)
- Heat-cool-heat DSC analysis of cocrystal 2 (.001)


NON-SINK DISSOLUTION
- UPLC analysis of LDM (Form A) FaSSIF solubility (.pdf)
- UPLC analysis of LDM PBS solubility and PBS dissolution experiment samples (.pdf)
- UPLC analysis of FaSSIF dissolution experiment samples (.pdf)
- Calibration curve for PBS dissolution experiment (.xlsx)
- Calibration curve for FaSSIF dissolution experiment (.xlsx)
- XRPD analysis of LDM (Form A), LDM-MEL and physical mixture dissolution samples after 2 & 24hrs in PBS (.xy)


MICRONISATION
- XRPD of alpha lactose monohydrate (.xy)
- XRPD of LDM-MEL after milling with and without lactose (.xy)
- mDSC of LDM-MEL after milling with and without lactose (.001)
- XRPD of LDM-MEL after conditioning with and without lactose (.xy)
- mDSC of LDM-MEL after conditioning with and without lactose (.001)
- SEM images of LDM-MEL after conditioning with and without lactose (.tif)