Non-Mimetic Gels Direct Novel Crystallization Behavior of Lenalidomide
Martin A. Screen,[1] Juan A. Aguilar,[1] Toby J. Blundell,[1] James F. McCabe,[2] Sean Askin,[3] Clare S. Mahon,[1] Mark R. Wilson,[1] Jonathan W. Steed[1,*]

[1] Durham University, Department of Chemistry, South Road, Durham DH1 3LE, United Kingdom
[2] Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, United Kingdom
[3] Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom. 
*Tel: +44 191 334 2085
Email: jon.steed@durham.ac.uk



List of DOI contents:

GELATOR CHARACTERISATION
- 1H NMR (400.20 MHz, DMSO-d6) spectra of G1 and G2 (.jdx)
- 13C NMR (100.63 MHZ, DMSO-d6) spectra of G1 and G2 (.jdx)
- ESI Mass spectrometry of G1 and G2 (.zip)

LDM CRYSTALLIZATION
- XRPD patterns of LDM crystallized from 9 solvents (.xy)

RHEOMETRY
- Stress and frequency sweeps for G1 and G2 gels with and without LDM crystals (.rsl)

GEL-PHASE CRYSTALLIZATION OF LDM
- XRPD patterns of LDM crystallised from gels, and of control gels (.xy)

SCANNING ELECTRON MICROSCOPY
- SEM images for G1 and G2 gels at CGC and MGC, with and without LDM crystals (.tif)

NMR TITRATIONS
- 1H NMR spectra from NMR titrations of gelators G1/G2 and LDM (.jdx)

DIFFUSIOMETRY
- DOSY spectra (DMSO-d6) for gelator G1/G2 solutions with LDM (.jdx)

NMR OF HEATED GEL
- 1H NMR spectra of G1 dioxane-d8 gel containing LDM at 25, 50 and 90 degrees C (.jdx)